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Formulation And Evaluation Of Nisoldipine Antihypertensive Drug with Solubility Enhancement

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Nishant Gaurav, Vipin Kumar, Mohd Faijan Mansoori, Ashish Kumar Birthare, Swati Wadhawan, Swati Dhuriya, Deepak Singh Aswal
» doi: 10.31838/ecb/2023.12.si6.128


A nanoemulsion is a liquid dispersion comprising two immiscible liquid phases, such as an oil phase and a water phase, that is thermodynamically or kinetically stable . The technological approach for hydrophilic medium polar drugs is less effective, thus the use of a Poly δ-decalactonepolymer presents a potential strategy to improve this limitation.The optimized formulation obtained from formulation variables was then subjected to optimization with process variable. On varying stirring speed and time in respect to particle size was decreased. The optimized formulations have a particle size between 583-615 nm; PDI of0.657±1.8, 0.552±1.05, and 0.734±1.51were selected for loading of the drug for final formulations.The particle size and shape of nanoemulsions were not changed after drug encapsulation. the values of NNE1, NNE2, NNE3, and NNE5 formulation were found to be 6.3±0.04, 7.4±0.08, 6.7±0.06, and 7.0±0.09 units only. In all cases, pH showed the smallest changes. The pH value of the optimized nanoemulsion formulation NNE3 was found to be 6.6±0.06. demonstrating its suitability for oral administration. Drug entrapment efficiencies of different formulations i.e. NNE1, NNE2, NNE3, NNE4, and NNE5 were found to be 71.33±1.62%, 82.4±0.24%, 99.95±1.35%, 90.12±0.34%, and 79.03that showedto affect the encapsulation of drug. Stability studies were carried out at 40C and 250C.

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