The aim of this study was to define and assess dental caries, which is caused by the presence of bacteria in the biofilm (dental plaque) on the surface of teeth, leading to the localized disintegration of the hard tissues. This disintegration is mostly caused by acids. These "cavities" are known as dental caries. Using Azadirachta indica and Curcumin, which have antimicrobial, antibacterial, antiplaque, and anti-inflammatory properties, a herbal effervescent mouthwash tablet was developed as a solid oral hygiene preparation due to the drawbacks of commercially available liquid mouthwashes with artificial active ingredients, such as tooth discoloration, increased alcohol content, peculiar tastes, xerostomia, and stability issues. This study focuses on formulation and investigates how adherence, biofilm accumulation, and cellular floor hydrolysis are affected by the extracted product from natural formulation. Staphylococcus aureus, Bacillus pummels, Bacillus subtilis, Acinetobacter baumannii, Micrococcus Lyle, and Pseudomonas aeruginosa are the bacteria used in this investigation.