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ISSN 2063-5346
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Formulation and evaluation of herbal based capsule and soft chew for liver disorders

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Manisha Kamble,Rajesh Verma,Pankaj Kumar Sharma,Rahul K. Dumbre,Jaya SharmaNaveen Kumar Singhal
» doi: 10.31838/ecb/2023.12.3.134

Abstract

Chronic liver diseases (CLD) represent a major health burden worldwide. According to WHO, approximately 75% of people use herbs to treat CLD globally. The plants traditionally used by native healers to support CLD have been the subject of extensive research in recent years. The combination of herbal plants such as Swarnakshiri, Guduchi, Pipali, and Haridra, Bhringraj was used as an Ayurvedic treatment of diseases. The study aimed to formulate the selected plant extract's hard gelatin and soft chewable capsules with the wet granulation method. The extraction of plant materials was carried out by the Soxhlet extraction method using aqueous water-alcohol media. A chromatographic study was performed to identify active constituents which include Berberine, Tinosporoside, Piperine, Curcumin and Wedelolactone respectively. The hard gelatin capsule was formulated by a combination of Berberine, Tinosporoside, and Piperine, and the soft gelatin capsule was formulated by a combination of Curcumin and Wedelolactone. Capsules were evaluated. The batch F7 optimised was selected for dissolution study for both formulations, weight variation, pH determination, disintegration and dissolution test. Both types of capsules showed 50% of drug release within 2h in buffer and HCl media. The stability study was performed for the prepared formulations for 6 months and the results obtained do not show any significant changes in the drug release profile two formulations. The study's findings suggest that the prepared formulations provide a long-term, safe, and permanent cure for liver disorders with better patient compliance and no side effects.

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