The study's goal was to formulate a Losartan drug delivery method with improved gastro retention. The tablets were prepared using Guar Gum, Micro Crystalline Cellulose, HPMC K4M and HPMC K100 LV in a direct compression process. To shorten the floating lag time, sodium bicarbonate was employed as the gas-generating agent. The tablets' hardness, weight fluctuation, thickness, floating capacity, swelling index, medication content, and in vitro dissolution study all underwent evaluation. Losartan Potassium tablet formulation with code LF4 could only sustain the release of respective drug till 12 hours.