Rolling circle amplification (RCA) has recently emerged as a potent way for producing regularly organised DNA structures, in addition to its long-established ability to improve biological signals. The method for producing nano-scaled cocoon-like DNA particles, nicknamed DNA nanoclews, for transporting and distributing tiny amounts of chemotherapeutic drug is presented here. The researchers were able to control the timing and location of drug discharge by encapsulating the DNA-degrading enzyme DNase I in a polymeric nanogel. Using endosomal acidity as a trigger, this clever drug delivery system based on RCA amplicons may penetrate specific cells and release the payload.