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ISSN 2063-5346
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FORMULATION AND CHARACTERIZATION OF OROXYLUM INDICUM LOADED PHYTOSOMESUSING BOX-BEHNKEN DESIGN

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Anil V. Chandewar, Nitin I. Kochar, Abhijit V. Shrirao, Sujit T. Karpe
» doi: 10.31838/ecb/2023.12.s2.228

Abstract

Phytosomes are a novel type of drug delivery system prepared by the incorporation of an active drug into the phospholipid vesicles. The present study was conducted to formulate and characterize phytosomes of Oroxylum indicum, an important medicinal plant, using Box-Behnken design. The independent variables studied were the concentrations of phospholipids cholesterol and dichloromethane, while the dependent variables were the particle size and entrapment efficiency of the phytosomes. The optimized formulation of Phytosomes OPF2 of Oroxylum indicum has been shown to be an effective drug delivery system, as it has been found to effectively improve the bioavailability of this medicinal plant extract. This is due to the unique physical structure of Phytosomes. The results of this study indicated that the Phytosomal formulation was more effective in enhancing the solubility and dissolution rate of Oroxylum indicum compared to the drug alone. This suggests that the Phytosomes of Oroxylum indicum could be a promising delivery system for this plant extract. The results of the study suggest that Box- Behnken design is a suitable approach for optimizing the formulation of phytosomes of Oroxylum indicum and other active drugs

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