Background: Female infertility has a complex pathophysiology that we still don't fully understand. One of the most studied pathogenetic pathways is how old mothers affect their children. The impact of oxidative stress on female infertility is unknown, but both of these conditions are linked to it. Inadequate antioxidant defenses relative to reactive oxygen species (ROS) generation characterizes oxidative stress. ROS, despite being present only in physiological states, serve a crucial regulatory role in the female reproductive system. When there are too many of them, they could have a negative effect on fertility. Coenzyme Q10 (CoQ10) is a lipid-soluble quinone that aids in the body's energy generation cycle by aiding ATP synthesis and functioning as a potent antioxidant that prevents lipid peroxidation and DNA oxidation. Despite a lack of clear data, CoQ10 supplementation has long been used to improve infertility outcomes and is related with a higher clinical pregnancy rate (CPR). The impact on ART clinical outcomes, including live birth rate (LBR) and miscarriage rate (MR), are also unclear. Oocyte quality is significantly affected by the oocyte's surroundings. Because the oocyte finishes developing in the FF, its biochemical characteristics may be crucial to the quality of both the oocyte and the embryo that develops from it. The flow of nutrients, oxygen, and other growth agents between oocytes and cumulus cells is bidirectional. Previous studies linked the presence of these components in the follicle to better oocyte quality and higher conception rates.