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Folate receptor targeted naringenin gold nanoparticles exhibit excellent in vitro antioxidant potential

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Debjani Chatterjee, Rimpa Malakar , Sounik Manna, Tamanna Roy, Surya Kanta Dey, Rumi Mahata, Subhabrata Das, Suman Mondal, Ahana Sinha, Ananya Pradhan, Sujata Maiti Choudhury
» doi: 10.31838/ecb/2023.12.si6.100


The present investigation revealed that the bio molecules present in citric phyto-compound naringenin are responsible for the synthesis of AuNPs and modified by folate (NAR-AuNPs-F). Characterizations of newly synthesized targeted nanoparticles were confirmed by Dynamic Light Scattering ( DLS) study and Fourier Transform Infrared (FTIR) spectroscopy. In assessing the chemo-preventive nano drugs, their antioxidant properties are broadly appraised. From this perspective the antioxidant activity of biogenic folate modified naringenin gold nanoparticles (NAR-AuNPs-F) was assessed. In vitro antioxidant activity was evaluated through the measuring 2,2- diphenyl-1-picrylhydrazyl, nitric oxide, superoxide, and lipid peroxidation scavenging activities. DLS measurement confirmed the nanoscale size of freshly prepared NAR-AuNPs-F that was 148 nm. FTIR analysis showed the presence of various functional groups i.e. hydroxyl, C=N which were responsible for the reduction and capping of AuNPs. It was found that nitric oxide, DPPH, lipid peroxidation, superoxide anion, scavenging actions of NAR-AuNPs-F treated groups were nearly similar to the standard antioxidant, ascorbic acid. The findings confirm1 that NAR-AuNPs-F may be an effective phytochemical based antioxidants agent.

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