In this present review, Fecal markers such as calprotectin, lactoferrin, zonulin and alpha-antitrypsin are found in stool samples and show elevated in Parkinson’s Disease Patients. Fecal markers are the biologically active protein which is released in the stool either leaked from the gut or released by the intestinal mucosa. As per case studies cited in the review reveals that calprotectin and lactoferrin are responsible for Intestinal inflammation however, zonulin and alpha-antitrypsin are responsible for intestinal permeability in PD.