The goal of any drug delivery system is to provide therapeutic amount of drug to the proper site in the body and also to achieve and maintain the desired plasma concentration of drug for a particular period of time. Colchicine is used for the treatment of gout, pseudo-gout and familial Mediterranean fever. It is known to have low therapeutic index and low oral bioavailability due to extensive first pass effect, and also associated with sever gastrointestinal side effects following oral administration. To overcome its oral intake drawbacks, colchicine loaded microsponges gels were prepared in an attempt to deliver the drug transdermally. colchicine is reported to cause local pain, inflammation at injection site and first pass metabolism, gastrointestinal (GI) side effects respectively. Hence an alternative topical drug delivery system has been proposed in the form of microspongel gel for its simplicity of application, higher patient compliance and controlling the drug release. The drug loaded microsponges were prepared employing emulsion solvent evaporation method using xanthan gum. Further the drug loaded microsponges were incorporated into carbopol base gel. The formulations were characterised on several parameters such as pH, drug content, viscosity and spreadability and stability studies and showed satisfactory results. The results from FTIR study showed no drug excipient interactions. In vitro drug release studies were done to check the formulations’ efficacy and the results showed sustained release of drug in colchicine loaded microspongel gel formulation as compared to control gel formulation. The study concluded that the procedure for making Colchicine microspongal gel is straightforward and repeatable.