Introduction: Although it must have become routine practice, immunohistochemistry for PTEN and p53 is becoming gradually available for population in need in resource limited countries. Objectives: To explore the PTEN and p53 gene immunoexpression in atypical endometrial hyperplasia and endometrial malignancies in perimenopausal women presenting with abnormal uterine bleeding and to assess their prognostic significance. Material and method: in this retrospective study patient files were retrieved for relevant informations, histological diagnosis was reviewed and fresh unstained slides from paraffin embedded tissue blocks were prepared for IHC. Immunoexpression of cases against the suitable controls were interpreted, scored and analysed.