Burn wounds are a significant cause of morbidity and mortality worldwide, necessitating the development of novel therapeutic strategies. This study aimed to conduct a comparative analysis of the potential wound healing effects of a polyherbalnanoethosome formulation containing PortulacaOleracea, Basellaalba, Trigonellafoenumgraecum, LawsoniaInermis, and Peristrophepaniculata. The selected plant species are renowned for their traditional use in wound healing and possess diverse phytochemical profiles with reported antioxidant, antiinflammatory, antimicrobial, and regenerative properties. Nanoethosomes[1] were utilized as a delivery system to enhance the bioavailability and efficacy of the herbal extracts. The polyherbalnanoethosome formulation was prepared using a thin film hydration method and characterized for particle size, encapsulation efficiency, and morphology