Gastric ulceration is one of the common GIT troubles. Numerous orthodox medicines are practiced worldwide for its treatment, but prolonged use is associated with several adverse effects. Today doctors have shown a growing interest in herbal therapies due to fewer side effects. The present study investigates the antiulcer activity of hydroethanolic extracts of Curcuma longa L. (CE) and Glycyrrhiza glabra L. (GE) with Vitamin M & B12 on albino rats against indomethacin-induced gastric ulcer model. Animals were divided into 11 different groups (n=6) i.e. normal control (I), negative control (II), vehicle control (III), positive control (IV), and treated groups (V-XI). Doses were prepared as suspension in 1% w/v CMC in dH2O. Gastric ulceration was induced via indomethacin suspension (20 mg/kg, p.o.) in II to XI besides I group. Ranitidine (20 mg/kg, p.o.) was used as a reference anti-ulcer drug as per prior reports and literature reviews. Suspensions of single-dose/day were administered to animal groups IV to XI for 15 days via oral gavage. Stomach was instantly removed after animal sacrifice. Gross lesion and histological examinations were carried out. Mean ulcer score, ulcer index, and percentage of ulcer inhibition were tabulated for the II-XI group. Gastric contents were also assessed to find total acid output, pepsin activity, and mucin contents. The obtained results revealed that oral doses of CE and GE markedly lowered ulcer index as compared to control groups. The extracts also noticeably decreased the total acid output and pepsin activity in treated groups. Pre-treatment’s of animals with 2 mg/kg of vitamin M and 50 μg/kg of vitamin B12 prevented ulcer formation. These findings demonstrated that hydroethanolic CE and GE extracts as well as Vitamin M & B12 also exhibiting marked gastric ulcer protection.