Introduction: Rheumatoid arthritis is a chronic systemic disease characterized by systemic features and joint involvement and it can lead to significant morbidity and mortality. The etiology of the disease could be attributable to genetic and nongenetic factors as hormonal, environmental, and infectious factors. Altered lipid levels have been reported in various inflammatory diseases including RA. There is an increased risk of atherosclerosis and cardiovascular disease in RA subjects than in the general population. Aim: The present study was planned to evaluate and compare the levels of serum HDL and LDL between RA patients and healthy controls. Methodology: Total of 80 subjects, 40 were patients with RA while 40 were age and sex matched healthy controls. Results and Discussion: The majority of patients were female. Decreased levels of HDL and Increased levels of LDL were observed in RA patients than controls.