β-N-Oxalyl-L-α, β-diaminopropionic Acid (L-ODAP) a neurotoxin and glutamate analogue from Lathyrus sativus seeds known to cause Neurolathyrism. Recent studies from our laboratory, indicated that L-ODAP induces Hypoxia and down regulates PEBP1. Hippocampal cholinergic neuro stimulating peptide (HCNP), increases acetylcholine synthesis derivative of HCNP precursor protein (HCNPpp), known as PEBP1 Decreased expression of PEBP correlated with accumulation of Abeta. Several publications indicated that down-regulation of PEBP results in the progression of Parkinson’s Disease (PD). We hypothesize that consumption of Lathyrus pulse might be a risk factor for PD. Thus, the present proposal aims to explore chemically induced PD mice models and control mice fed with the Lathyrus diet and score for PD. we investigated behavioral parameters like tremors, rigidity, akinesia, and postural reflexes by inducing Parkinsonism in experimental animals (C57BL/6 strain mice n=6) using the injection of neurotoxins MPTP. We analyzed the data of statistical and histopathological evidence that L-ODAP does not cause any neurological damage to induce Parkinsonism in mice. The current study supports fresh statements that L. sativus is a hypothetically important useful food with high value to human health in areas of cardiovascular physiology, hypoxia, and nutrition since it contains both homoarginine and L-ODAP. According to a scientific study, consuming L. sativus as part of a regular diet is beneficial to health.