The present study investigates the “EVALUATION OF CYTOPROTECTIVE EFFICACY OF CURCUMA CAESIA AGAINST CYCLOPHOSPHAMIDE (CPY) INDUCED CARDIOTOXICITY” in Swiss albino mice. In traditional medicinal system different parts of the plant have been mentioned to be useful in a variety of diseases. The rhizome of Curcuma caesia contains bioactive components such as curcuminoids which is responsible for anti-oxidative, anti-inflammatory properties, wound healing, hypoglycaemia, anti-coagulant and anti-microbial activities The objective of the present study was to evaluate the cytoprotective efficacy of methanolic extract of curcuma caesia (rhizome) against cyclophosphamide (oncolytic agent) induced cardiotoxicity in Swiss albino mice by various haematological (RBC, WBC & Hb) biochemical analysis (serum analysis).Animals were divided into four groups of six animals each, total 24 animals were taken for this performing this activity. Group-I (control) received normal saline 1 ml/kg for two days. Group-II (positive control) received only cyclophosphamide drug at the dose of 200mg/kg; i.p on 0th days for 48 hours. GroupIII & IV received 250mg/kg and 500mg /kg of methanolic extract of rhizome of curcuma caesia prior 30 minutes before the administration along with CYP (200mg/kg; i.p) respectively for two days. The results showed that the efficacy of methanolic extract of curcuma caesia is potential towards the cardiotoxicity produced by the CYP on the tested animals during experiment. After the evaluation of certain parameters such as organ body weight index, WBC, RBC and Hb levels, serum LDH and creatinine kinase enzyme levels etc. we can conclude that the curcuma caesia shows effective results against the CYP induced cardiotoxicity (p<0.05) as compared to control group at a regular interval of 2-hour readings for 2 days. There was dose dependent decrease in cardiotoxicity volume in ethanolic extract treated groups. The methanolic extract (250mg/kg and 500mg/kg) significantly (p<0.05) and dose-dependently inhibited the cardiotoxicity induced by CYP.