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ISSN 2063-5346
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EVALUATION OF ANTIOXIDANT ACTIVITY OF CINNAMIC ACID AND SOME OF ITS DERIVATIVES

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Olawale H. Oladimeji,[a]* Aniekeme E. Essien,[a] Arthur J. Sheriff[a] and Taiwo E. Alemika[b]

Abstract

Cinnamic acid, chemically known as 3-phenyl-2-propenoic acid is has a broad spectrum of pharmacological actions including antioxidant activity. The esterification and selective reduction of the acid led to ethyl cinnamate and cinnamyl alcohol, respectively. Cinnamic acid demonstrated a poor antioxidant activity (IC50) of 1.2 μg mL-1 while ethyl cinnamate and cinnamyl alcohol elicited activities of 0.64 μg mL-1 (moderate) and 0.84 μg mL-1, respectively. The obtained results indicate that esterification enhances the antioxidant activity of cinnamic acid.

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