Epilepsy is a neurological disorder characterized by recurrent seizures, affecting millions of people worldwide. Despite the availability of several anti-epileptic drugs, there remains a need for more effective and safer treatment options. Nigella sativa, commonly known as black seed or black cumin, is a medicinal plant with a long history of use in traditional medicine. This study aimed to evaluate the anti-epileptic potential of the ethanolic extract of Nigella sativa in validated animal models of epilepsy. The ethanolic extract of Nigella sativa was prepared, and its chemical composition was analyzed to identify the presence of bioactive compounds. Validated animal models of epilepsy, including pentylenetetrazole (PTZ) and maximal electroshock (MES) models, were used to induce seizures. The animals were orally administered with different doses of the ethanolic extract of Nigella sativa, and seizure severity, duration, and frequency were recorded. The results of this study demonstrated that the ethanolic extract of Nigella sativa significantly reduced seizure severity, duration, and frequency in both PTZ- and MES-induced seizure models. The anti-epileptic effects were found to be dose-dependent, with higher doses of the extract exhibiting greater reductions in seizure activity. These findings suggest that the ethanolic extract of Nigella sativa possesses anti-epileptic potential.