Several adjuvant drugs have been used in combination with the epidural local anesthetic in order to improve the quality of motor block and prolong the duration of postoperative analgesia. These adjuvants include opioids as morphine, fentanyl and sufentanil, α-2agonists as clonidine and dexmedetomidine, magnesium sulphate and neostigmine. Aim: to compare the onset and duration of sensory and motor block, as well as hemodynamic changes and level of sedation following epidural levobupivacaine supplemented with dexmedetomidine and fentanyl in patients undergoing arthroscopic knee surgeries. Methods: Prospective, double blind randomized clinical study, Patients undergoing arthroscopic knee surgeries, Ninety Patients were randomly allocated into three equal groups