Interdisciplinary collaboration between pharmacists, nutritionists, and pediatricians has the potential to significantly improve the quality of care provided to pediatric patients. However, realizing the full benefits of these collaborations requires overcoming barriers. This review explored the importance of interdisciplinary teams in pediatric care, examining the distinct roles of pharmacists, nutritionists, and pediatricians in addressing the unique needs of children and adolescents. Key areas of collaboration are discussed, including the management of medication-nutrient interactions, provision of nutritional support, optimization of pharmacotherapy, and dietary interventions for pediatric conditions. Effective collaboration models are highlighted through case studies and best practices. Challenges such as healthcare fragmentation, limited resources, and inter-professional conflicts have been addressed. Future directions are discussed, including interprofessional education, integration of technology, and personalized nutrition approaches. Overall, this review demonstrates that an interdisciplinary, team-based approach to pediatric care can enable comprehensive assessments, coordinated treatment plans, and tailored interventions that improve outcomes. Further research is needed to advance evidence-based, patient-centered collaborations between healthcare professionals caring for pediatric patients.