Oral submucous fibrosis (OSMF) is a chronic disease of the oral cavity including pharynx which is most encountered in patients chewing areca nut in the Indian subcontinent. It is characterized by the formation of constricting bands of collagen in the oral cavity which can severely restrict mouth opening, and tongue movement can lead to difficulty in swallowing and chewing for the patients. There are various treatment modalities for the management of OSMF where in recent research has shown strong promising effects of pentoxyphylline for treating OSMF. Method: A study of 132 clinically and histopathologically diagnosed patients with OSMF was done. They were prescribed oral pentoxifylline 400mg twice a day for a period of 4 weeks and 400mg thrice a day for another 4 weeks. Along with medicinal therapy patients were strictly advised to do physiotherapy exercises like warm water gargles twice a day, ballooning exercises, ice cream stick exercises. Results: Statistical analysis was done and it was found that burning sensation was reduced by 75.8%, tongue protrusion was increased by 50%, fibrosis was reduced by 55%. The total reduction in signs and symptoms score was 56.6%. Conclusion: In present study we found that the relapses were less as physiotherapy exercises were advised along with pentoxyphylline drug. Pentoxyphylline is good substitute to injectable management of OSMF as patient compliance is more as compared to injectable, also the drug is easily available and very cheap as compared to other treatment modalities.