Aim: This study aims to evaluate the efficacy of local anesthesia with and without vasoconstrictors using Gow- Gates and classical inferior alveolar nerve block techniques. Materials and method: This study includes 4 groups with each group having 10 patients, Group I included administration of local anesthesia without vasoconstrictor by Gow-Gates technique, Group II included classical inferior alveolar nerve block without vasoconstrictor and Group III included administration of local anesthesia with vasoconstrictor using Gow-Gates technique and group IV included classical inferior alveolar nerve block with a vasoconstrictor. The effectiveness of the techniques was evaluated by probing the regions innervated by the inferior alveolar, lingual, and buccal nerves, and also by assessing pain during injection, time of onset of lip anesthesia, complete lip anesthesia, and any associated complications. Results: The mean time of onset for anesthesia for Gow Gates without vasoconstrictor was found to be 6mins 5 secs, Gow Gates with vasoconstrictor was 8 mins 20 secs, Classical IANB without vasoconstrictor 5mins 18 secs, and for Classical IANB with vasoconstrictor was 6mins 40secs. Significant results were found between all the groups for the onset of anesthetic action, except between the Gow Gates technique without vasoconstrictor and Classical IANB technique wa ith vasoconstrictor. Discussion: Since there is no significant difference between onset of time of anesthesia between Gow Gates technique without vasoconstrictor and classical IANB technique with vasoconstrictor, Gow Gates technique without vasoconstrictor shows to have similar efficiency to that of classical IANB technique with vasoconstrictor. Conclusion:Since the result of any clinical studies involving anaesthetic techniques require subjective findings, its advantages become significant only after repetitive studies. Further studies should be done to establish that Gow Gates technique without vasoconstrictor shows better efficacy than Classical IANB technique.