Voice is the most important factor in our day-to-day lives; it is the primary means by which humans and countless other animals communicate with one another to share information and ideas. Voice disorders can be caused by structural & /or functional alterations in the larynx, which prevent the voice from being able to fulfill the functional requirements of the speaker. This condition affects approximately thirty percent of the population at some point in their lives. Vibratory trauma appears to be the primary cause of minimum associated pathological lesions at the present time. Phonosurgery, pharmacology, technical equipment, and behavior modification voice treatment are the four primary approaches that can be taken to treat vocal issues. Phonosurgery is the most common approach. Vocal fold injection, also known as VFI, is a method that is considered to be minimally invasive that administers a variety of medications or materials into the tissues of the larynx. Because of developments in material science & endoscopic technology, this method has made a comeback, & its application in the field of laryngology has been brought to the forefront. The extracellular matrix protein known as hyaluronic acid has a significant role in the biomechanics of the vocal fold's movement. In certain circumstances, the overproduction of HA and the retention of HA in the superficial lamina propria of the vocal folds (SLP) can lead to the placement of the HA into the SLP, which can result in a decrease in the quality of the voice. By enzymatically cleaving HA, the HAase enzyme, also known as hyaluronic acid, is able to breakdown HA. Both the permeability of connective tissues and the amounts of HA are decreased as a result of HAase-mediated breakdown.