The present study was conducted to assess the effect of SIM on knowledge of correct body mechanics in prevention of low back pain among staff nurses. Methods: - An experimental design was chosen with one group pre test- post-test research design. The sample size was 60 registered Staff nurses. The data was collected by using a self structured questionnaire focusing on knowledge on proper body mechanics in prevention of low back pain among staff nurses. The data were analyzed with the help of descriptive and inferential statistics. Result:- The study clearly shows that there was a significant gain in knowledge of Staff nurses which emphasizes that proper body mechanics is necessary for the prevention of low back pain. Conclusion:- The Staff nurses can be benefited with SIM to improve knowledge on correct body mechanism in prevention of low back pain.