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ISSN 2063-5346
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EFFECTIVENESS OF INTRAOPERATIVE DEXMEDETOMIDINE INFUSION IN ENHANCING SURGICAL FIELD VISUALIZATION DURING ENDOSCOPIC SINUS SURGERY: A RANDOMIZED STUDY

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Vidushi Sharma, Akash Nirmal, Sanjay Kumar, Pallavi Singh, Pradeep Sahi, Arun Gupta
» doi: 10.31838/ecb/2023.12.si6.065

Abstract

Background: Endoscopic sinus surgery (ESS) is a commonly performed surgical intervention for treating chronic rhinosinusitis (CRS). However, intraoperative bleeding and inadequate surgical field visualization are common challenges that surgeons face during ESS. Intraoperative dexmedetomidine infusion has been investigated as a potential solution to enhance surgical field visualization during ESS. Materials and Methods: A randomized controlled trial was conducted to investigate the effectiveness of intraoperative dexmedetomidine infusion in enhancing surgical field visualization during ESS. Patients undergoing ESS for the treatment of CRS were randomized to receive either dexmedetomidine or a placebo infusion. The primary outcome was the quality of the surgical field as assessed by the surgeon using a standardized grading scale. The secondary outcomes included the amount of intraoperative bleeding, the need for hemostasis, and the incidence of adverse events. Results: A total of 80 patients were enrolled in the study, with 40 patients in each group. The quality of the surgical field was significantly better in the dexmedetomidine group compared to the placebo group (p<0.001). The amount of intraoperative bleeding was significantly lower in the dexmedetomidine group (p<0.001), and the need for hemostasis was also significantly lower (p=0.01). There were no significant differences in the incidence of adverse events between the two groups. Conclusion: Intraoperative dexmedetomidine infusion is an effective approach to enhance surgical field visualization during ESS. It significantly improves the quality of the surgical field, reduces the amount of intraoperative bleeding, and decreases the need for hemostasis. Dexmedetomidine appears to be safe and welltolerated in patients undergoing ESS for the treatment of CRS.

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