Clinical success of dental implant depends on the biomechanics and proper distribution of the occlusal load, many material combinations including metal/acrylic, metal/ceramic, BioHPP (high performance polymer) and zircon/ceramic can be used for all on four implant frameworks. Aim: The aim of this in-vitro study is to compare the effect of two different all-on-four framework materials on stresses induced in the supporting structures of implants. Methodology: In-vitro study using strain gauge technology on 3D epoxy printed resin models are conducted to strain gauge measuring micro strain induced by different fixed detachable dental prosthesis materials (all zirconia fixed detachable prosthesis and BioHPP fixed detachable prosthesis) supported by implant using all-on-four treating concept, each prosthesis will contain 12 teeth with the distal cantilever. For each model, the load was applied five times vertically and obliquely to ensure the reproducibility of the results, Results: Statistical analysis showed a significant difference between Bio HP and zirconia for the microstrains around the implants (p=0.008), the zirconia group recorded high values (60.00±5.30) than Bio HP (18.75±2.15), conclusion: BioHPP framework has shown to be less traumatic to all on four implants especially in unilateral loading. So, it was recommended to be used as frameworks material for fixed detachable prosthesis.