Background: The role of the quadrant location in the prediction of the breast lesion prognosis has been a matter of research for a long time with no definitive results being reported. Aim: To assess the prevalence of breast lesions in different quadrants, to assess the role of various Quadrant locations in breast lump prognosis, and to evaluate the breast lump nature by cytomorphological analysis. Methods: An assessment of the quadrant location was done followed by a detailed physical, radiographic, and clinical examination. In all study subjects, lymph nodes, axilla, and bilateral nipple examination were done. FNAC was done for cytomorphologic examination following staining. Results: Both fibroadenoma and IDCC were most common in lateral upper quadrant with 58.62% (n=34) and 70% (n=14) subjects. In 30% (n=6) subjects, IDCC was seen in medial upper quadrant. Fibroadenoma was seen in 10.34% (n=6) subjects in lateral lower quadrant, in 13.79% (n=8) subjects in medial upper quadrant, in 10.34% (n=6) subjects in central, and in 6.89% (n=4) subjects in medial lower quadrant. Conclusion: Fibroadenoma and invasive ductal cell carcinoma are the most common benign and malignant lesions with the most common occurrence in the lateral outer quadrant and a better prognosis was seen in the upper lateral quadrant.