Background: Nocturnal enuresis (NE) had the worst impact on the standard of lifetime of postmenopausal women. The aim: This study aimed to identify and investigate the impact of core strengthening exercises on postmenopausal nocturnal enuresis. Methods: Sixty women with postmenopausal nocturnal enuresis participated in this study. They were aged from 50 to 65 years. They were randomized into 2 equal groups. Group (A) included 30 women who recruited only in pelvic floor exercises program 3 times /week for 12 weeks. Group (B) included 30 women who participated in pelvic floor and core strengthening exercises program 3 times /week for 12 weeks. The pelvic floor muscles strength was measured utilizing a perineometer. frequency volume chart (FVC) was used to measure fluid intake, urine output, voiding and leakage frequencies. International Consultation on Incontinence Questionnaire–Short Form (ICIQ-SF) was utilized to assess quality of life of the women. The results: The results showed a significant improvement in pelvic floor muscles strength in both groups with significant difference among the two groups (p=0.04). According to FVC, there was a significant decrease in voiding and leakage frequencies in both groups with significant difference between the two groups (p=0.03 and 0.02 respectively). Fluid intake and urine output had no significant differences in both groups. The ICIQ-SF also showed significant improvement in both groups, but also there was a statistically significant difference among them (p=0.04). Conclusion: Core strengthening exercises were effective for improving pelvic floor muscles strength and quality of life in postmenopausal nocturnal enuresis.