Chronic kidney disease is a non-communicable disease with growing prevalence rates. It usually affects the adult and aging population. Its prevalence is higher in South Asian people because of the higher incidence of metabolic abnormalities. Decreased glomerular filtration rates and damage to the renal structure are the characteristic features of the disease. Controlling the causative factors is the only management strategy to halt its progression to end-stage renal failure. The lack of therapeutic drugs for CKD makes it an essential area of research. Flavonoids are polyphenolic molecules currently investigated primarily because of their multiple pharmacological activities. This study aimed to investigate the renoprotective properties of diosmin in adenine-induced chronic kidney disease. Diosmin is proven to be a renoprotection agent against the experimental model through its anti-inflammatory and anti-fibrotic properties.