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ISSN 2063-5346
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DEVELOPMENT OF NOVEL ANTIINFLAMMATORY DRUGS TARGETING THE COX-2 ENZYME

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Dr. Nalini Kanta Sahoo1,Dr. Vatsala Tomar2,Prashanth Kumar H P3,S. Violet Beaulah4,Dr. T. Ramesh5,Nagaraju Bandaru6
» doi: 10.48047/ecb/2023.12.Si5.385

Abstract

Prostaglandin end peroxide synthase, also known as cyclooxygenase, is a crucial enzyme in the conversion of arachidonic acid to prostaglandins (COX). Both COX-1 and COX-2 are COX isoforms. In contrast to COX-1, which is often generated constitutively, COX-2 is easily induced (for example, in sites of inflammation and malignancy) (eg gastric mucosa).

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