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ISSN 2063-5346
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DEVELOPMENT & ASSESSMENT OF COLON TARGETTED MICROSPHERES OF BOSWELLIC ACID USING SODIUM ALGINATE & CALCIUM CHLORIDE BY IONIC GELATION TECHNIQUE

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SAGAR D. KORE*,Dr. PANKAJ SHARMA,Dr. RAHUL DUMBRE,Dr. Jaya Sharma,Dr. NAVIN KUMAR SINGHAL,BASVRAJ MATHDEVRU,
» doi: 10.31838/ecb/2023.12.3.139

Abstract

Background:This work is based on development of microspheres of boswellic acid for colon targeted drug delivery. Method: Microspheres were prepared using sodium alginate, calcium chloride by ionic gelation method.The prepared microspheres were evaluated for micromeretic properties, surface morphology etc. Levels of sodium alginate and calcium chloride were varied to obtain optimum composition for smallest possible particle size, maximizing entrapment efficiency and cumulative drug release at 6hr. The selected composition was used to prepare microspheres that were subjected to coating by Eudragit S100 in hydroalcoholic solvent system. Dissolution of these microspheres was studied by pH progression method. Drug release mechanism was found be characterized by swelling and erosion. Results: The microspheres showed good flow properties and spherical shape. The formulation was optimized and optimized models were found to be valid. It was observed that the microspheres prepared using 1.48 % w/v of sodium alginate and 4.71% w/v of calcium chloride showed optimum drug release of 89% at colonic conditions, 78% entrapment efficiency and 340 microns particle size. Conclusion: It was concluded that boswellic acid microspheres prepared using ionic gelation method and coated with Eudragit S 100 can be a promising approach for colon targeting

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