Objective: A simple novel, accurate, precise, and reproducible TLC-densitometric method for simultaneous estimation of Moxifloxacin HCl (MXF) and Ketorolac Tromethamine (KTA) has been developed for routine estimation. Methods: The proposed method was validated using ICH validation parameters like linearity, accuracy, precision, LOD and LOQ, recovery studies and repeatability studies. The chromatographic separation of the drugs was achieved on Merck precoated silica gel aluminium plates 60 F254 as the stationary phase and the solvent system consisting of mobile phase chloroform: methanol: Formic acid (8.5: 1.5: 0.05 v/v/v) was utilized. Densitometric evaluation was performed at 305 nm, which is the iso-absorptive point for the simultaneous estimation of both drugs.