Transdermal drug delivery offers an attractive alternative to the conventional drug-delivery methods of oral administration and injection. Nanocarriers have been developed for efficient drug delivery and diagnostic tools. Nanocarrier enables an effective, targeted biomolecular interaction in order to lower side effects caused during the treatment.Cancer therapies are currently limited to surgery, radiation, and chemotherapy. Nanotechnology offers the means to target chemotherapies directly and selectively to cancerous cells and neoplasms, guide in surgical resection of tumors, and enhance the therapeutic efficacy of radiation-based and other current treatment modalities.Nanocarriers as drug delivery systems are promising and becoming popular, especially for cancer treatment. In addition to improving the pharmacokinetics of poorly soluble hydrophobic drugs by solubilizing them in a hydrophobic core, nanocarriers allow cancer-specific combination drug deliveries by inherent passive targeting phenomena and adoption of active targeting strategies.γ-Oryzanol and its components have been evaluated for their anticancer propertiesγ -Oryzanol has a property to treat cancer and hyperlipidemia. It is not soluble in water due to this property γ -Oryzanol give very poor bioavailability but in the nano drug delivery with albumin it has good solubility and permeation ability.The present investigation attempted to find out the anticancer properties of γ-Oryzanol Loaded Albumin Nanoparticles.