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ISSN 2063-5346
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Development and In-Vitro Evaluation of Curcumin Proniosomes for Enhanced Stability and Antimicrobial Activity

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Kiran Yadav, Sandhya Jaishwal, Deepak Yadav, Sunil Kumar, Chetan Sharma, Kamal saroha, Sanju nanda
» doi: 10.31838/ecb/2023.12.sa1.174

Abstract

Curcumin is a natural polyphenolic compound derived from the rhizome of the turmeric plant. It has been reported to possess various biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. However, its low bioavailability limits its clinical applications. Proniosomes are an emerging drug delivery system that can improve the bioavailability of poorly soluble drugs, such as curcumin. In this study, proniosomal formulations of curcumin were prepared using different surfactants, including Tween 20, Tween 40, Tween 60, Span 20, Span 40, and Span 60. The vesicle size, drug entrapment efficiency, and stability of the formulations were evaluated. The results showed that Span 60-based proniosomes had the highest entrapment efficiency (78.77%) and stability at room temperature and refrigeration. This could be due to the high HLB value of Span 60, which is more suitable for forming niosomes than the lower HLB value Tween surfactants. The in vitro antimicrobial activity of curcumin proniosomes was evaluated against four strains of bacteria, including two Gram-positive (Bacillus subtilis and Staphylococcus aureus) and two Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. The highest zone of inhibition was observed against Bacillus subtilis (19.3 mm) and Staphylococcus aureus (17.6 mm) when combined with PEG. This could be due to the synergistic effect of PEG and curcumin on the bacterial cell wall. In addition, the free radical scavenging activity of curcumin was evaluated using the DPPH assay. The results showed that curcumin was more potent than ascorbic acid at all concentrations tested, indicating its potential as a natural antioxidant. Overall, the findings suggest that Span 60-based curcumin proniosomes could be a promising option for enhancing the stability and antimicrobial activity of curcumin

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