Objectives: The purpose of this study was to make sustained release bilayer tablets that release medicine slowly over a long period of time using Nifedipine model drug, natural and their modified form of gum like tamarind seed gum and fenugreek seed gum as release retardant. Methodology: Various amounts of tamarind and fenugreek seed gum natural and modified form were use and prepared eight different batches formulations of the nifedipine. The developed and optimized bilayered release matrix tablets were evaluated. Results: The evaluation results of nifedipine sustained release bilayer matrix tablets showed decent physical qualities. The in-vitro cumulative % drug releases from the tablets were exhibited best by the selected formulation same like as marketed formulation. It is clear that modified tamarind seed gum maintained a sustained release of 99.34% for up to 24 hours and modified fenugreek seed gum maintained a sustained release of 98.93% for up to 20 hours at a 40% concentration. Nifedipine tablet drug release according to the Higuchi or Hixson-Crowell model. Conclusion: By using the wet compression approach, the study was shown that blended hydrophilic natural and their modified form of polymers can be used to build sustained release bilayered matrix tablets for poorly soluble medicines.