Compliance describes a specific goal adherence to the treatment program, especially for patients with chronic diseases, is important. Ischemic stroke is a degenerative disease that causes death. Based on data on the number of ischemic stroke patients, there were 1117 patients during January 2021 – December 2021. This research aims to find out the causes that influence the regularity of participating in the Outpatient Treatment Program at the SK Lerik Hospital, Kupang. Study This is study qualitative with design crosectional . Determination of the sample in this study used total sampling of the average number of patient visits over 3 months. The number of samples taken was 63 patients. The variables examined in this study were age, gender, duration of illness, frequency of taking medication, income, trust in health workers, family support, self-efficacy and compliance with the treatment program. Based on the results of multivariate analysis using logistic regression tests, the variables that influence compliance with the coronation program for ischemic stroke patients are income with a p-value of 0.003, trust in health workers with a p-value of 0.004, family support with a p-value of 0.025, and self-efficacy with p-value 0.032. The conclusion is that what does not influence the compliance of ischemic stroke patients with the treatment program is that age, gender, frequency of taking medication, and duration of illness influence compliance with the treatment program of ischemic stroke patients, economic income, while trust in health workers, family support, and self-efficacy. Based on this research, it is recommended for families to help patients comply with existing treatment programs, as well as for health workers to build relationships of mutual trust and effective communication with patients to increase patient compliance with the treatment program provided.