The growth of the e-commerce industry in Indonesia shows a rapid increase, the dominant factor as a cause is the existence of very wide business opportunities that can be obtained from the potential of a large population. Opportunities for e-commerce companies are still wide open to develop their business with bright prospects. This research was conducted with the aim of getting an overview of the influence of a dynamic environment, dynamic capabilities, design thinking, partnership programs, eco-innovation programs, on the business performance of e-commerce companies in Indonesia. This study uses a quantitative approach with descriptive and explanatory survey types with the number of respondents as many as 65 companies. The object of research is an e-commerce company engaged in the marketplace and retail. Data analysis was performed using descriptive statistics and inferential statistics. The results of the descriptive analysis show that the dynamic environment, dynamic capabilities, design thinking, partnership programs and eco-innovation programs as well as the business performance of e-commerce companies in Indonesia are obtained as follows: The company's ability to adapt to a dynamic environment is in an influential position, dynamic ability is one of the variables studied showing a fairly influential position, design thinking strategies in e-commerce companies in Indonesia are quite influential, partnership programs in good e-commerce companies and eco-innovation programs in e-commerce companies' trade are good. The allocation of costs for implementing partnership and eco-innovation programs is supported by the management of partner companies.