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Design, Synthesis and Evaluation of New Compounds Potent Anticancer Agent

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Shraddha Vikram Tathe, Dr. Anwar R. Shaikh
» doi: 10.48047/ecb/2023.12.si6.163


Aim of the present study is design, synthesis and evaluation of potent anticancer activity of the Curcumin. But in these studies main focus on the breast cancer. Anticancer agent such as Tamoxifen, raloxifene, Toremifene and Fulvestrant but they have some limitation to treat for breast cancer. So we hypothesized that tamoxifen can be used as standard drugs and it may be helpful to develop antiestrogens should not only have good binding affinity with particular receptor but it also must have selective activation for that receptor which expressed in breast cancer progression. Therefore, selective ER α antagonists may be helpful for the breast cancer treatment. Curcumin’s antiproliferative effects are estrogen dependent in ER (estrogen receptor)-positive MCF-7 cells, being more pronounced in estrogen-containing media and in the presence of exogenous 17- estradiol.

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