The current study is an innovative attempt to create nanoemulgel (NEG) that incorporates the medicinal properties of argan and ginger oil to treat potentially fatal topical fungal infections. Every year, approximately 1.5 million people worldwide are killed by fungal infections. The essential oils used in this study were argan and ginger oil, both of which have strong antibacterial properties. Argan oil and ginger oil (1:1) were chosen for antifungal activity based on the Minimum inhibitory concentration (MIC) and zone of inhibition. The goal of this study was to create an argan and ginger oil-loaded nanoemulgel for transdermal administration using a box-Behnken statistical design. A three-factor, three-level Box- Behnken design was used to optimise the nanoemulsion. The independent variables investigated were oil concentration (A), Smix concentration (B), and stirring time (C). The best nano-emulgel was made with oil, Smix, and water in a 20:10:70 ratio in 3% HPMC K15 M gel has a globule size of nanoemulsion 185±3.4 nm and a PDI of 0.352 ± 0.102. As a result of the findings, it is possible to conclude that the NEG of argan oil and ginger oil would be an effective treatment for fungal infections.