Azilsartan is an AT1 receptor selective blocker., strongly fixes to the AT1 receptor and then progressively separates from it. This prevents angiotensin II from binding, Aldosterone actions are diminished and vasodilation is produced. The objective of this work was to use polymer to create a nanoparticulate drug delivery system for the hypertension medication Azilsartan ( poly vinyl alcohol). The produced loading of the formulation effectiveness, entrapment effectiveness, Zeta potential, particle size distribution, and drug polymer compatibility. The improved formulation F7 (drug 50 mg, polyvinyl alcohol 75 mg, 10 mg cyclodextin) had an entrapment efficiency of 99.38 ± 0.08 and a 24-hour in-vitro drug release of 98.46%. The diffusion and erosion mechanisms of release are likewise followed, and it also obeys the zero order. Lrbesartan nanoparticles were determined to be in the optimal range of surface shape and to be in the average nanometer range (358.4 nm) in the optimised formulation (F7), according to surface morphology. According to the results of the stability test, the formulation (F7characteristics)'s did not alter. Zeta potential measurements on the improved formulation (F7) were also looked at.