Emergency medical service/adjacent care setting is the indispensable terminus of the medical system, shouldering the duty to give immediate medical attention to patients suffering from acute illnesses. This paper critically analyzes patient safety and patient-centered care in the EMS and adjoining environments. This empirical research aims to critically review all the existing literature on patient safety measures, challenges, and improvement opportunities. The research accentuates the value of prioritizing patient safety and patient-oriented care in emergency medical operations as it suggests developing care delivery in these critical areas.