This critical review will analysis the relevance of this study and cover various nursing issues and how they impact the immune system of a child when she has a drug abuse problem. It is known that antibiotics are very effective in the case of bacteria causing infections, but these also lead to weakening the immune system of the infant. Immediate-to-skin care by nurses can take various forms, such as waking the mothers for breastfeeding, training the parents on appropriate antibiotic use, etc. All these are essential nursing interventions utilized to promote the newborn's immunity. After an investigational synthesis of literature and how and why nursing can be relevant in this particular case, this approach looks at things from another angle that could serve good purposes. Our assessment process involved a thorough review of all the literature and statistics coupled with such studies. The result and analysis figures, tables, and charts would be nicely displayed. "Self – made" is the part, whether I remembered it or not. The emergence of MDR bacteria results in the development of the medical guidelines of nursing care in the field of public health that might impede the improvement of the response to the antibacterial agents in children, which eventually could lead to the dismantling of their vaccination effectiveness.