Orthodontic therapy includes active and passive components which are formed by different types of metals, elastics, and polymers to manage various malocclusions. As these Orthodontic components come in contact with oral tissues they induce cytotoxic, allergic, inflammatory, or genotoxic reactions. Though the combination of metal alloys and other components used during treatment are biocompatible still it has been shown that metallic alloys release ions which are of significant clinical concern as the metals react with electrolytes in the oral cavity which includes saliva and other acidic or basic food items hence producing electrochemical reaction with oral tissues and causes biodegradation and corrosion. This article highlights the different Orthodontic components and their degradation process along with biological reactions which are responsible for alteration in the biocompatibility of metal alloys and further explores the forthcoming strategies to overcome the degradation process.