One of the most crucial trigger factors involved in developing chronic kidney disease (CKD) is diabetes, indicated by hyperglycemia or glycated haemoglobin (HbA1c). Hyperglycemia causes increased generation of reactive oxygen species (ROS). CKD is considered a similar condition that leads to an excess generation of free radicals. The resultant lipid peroxidation releases malondialdehyde (MDA) as its product, which indicates the degree of oxidative stress (OS). This study aimed to evaluate and compare HbA1c and oxidative stress (MDA)) among different stages of CKD, which can benefit to end or slow the advancement of the disease. Material and method-This study was conducted in Lucknow, India from November 2020 to April 2021. A total of 88 CKD patients were taken after applying exclusion criteria. HbA1c, MDA and eGFR was estimated and patients were classified into different stages of CKD. Association of CKD stages with age and gender was seen by Chi-square test. ANOVA and Post-hoc Tukey test were used to find out the difference in mean of HbA1c and MDA among CKD patients and the control group. Result-In this study, more than half of the CKD patients belonged to age of 40 to 59 years with CKD stage 5 being commonest. The association of CKD stage with age was seen to be non-significant, but with gender it was statistically significant. In our study mean difference of HbA1c was found to be significant among CKD stages and control. Level of MDA was found to be more in CKD patients and it increased progressively with CKD stages. Conclusion- Our study proves the association of hyperglycemia and oxidative stress with advancement of CKD. So, routine evaluation of these parameters and taking appropriate steps to reduce oxidative stress and glucose level may be of value in improving the survival of CKD Patients