Introdution: Annona muricatais a medicinal plant from Annonaceae family with a custard like texture. Each part of the plant contain various phytochemical constituents that contribute to medicinal activity. Some phytochemical constituents are acetogenins, coumarins, phenolic, alkaloids and flavonoids. Objective: This study aimed to identify the phytochemicals in Annona muricataleaves extract specifically phenolic and flavonoids and to evaluate the anti-oxidant activity by using two different types of solvents. Methodologies: Water and methanol were chosen as the solvents for extraction of the Annonamuricata leaves. This was to differentiate the yield of extraction of both solvents. Maceration is the extraction method that was chosen to extract the Annona muricataleaves. Freeze drying is the chosen method for drying purpose. Then, the extract was stored in the deep freezer to preserved it until it was ready to be used.