Recent time has seen a lot of studies being conducted to study various risk factors for cardiovascular diseases. LDL cholesterol is one such risk factor that has garnered a lot of attention. Most of the clinical practitioners are depending on laboratory reports where LDLC is done by Friedwald’s formula (FF) for their diagnosis. However, with evolving times and technology it is necessary to utilize advanced versions of available tests for accurate diagnosis and categorizing patients as higk risk coronary heart disease (CHD) patients. The aim is to conduct a comparative study of LDLC by direct method versus Friedewald’s formula (Calculated LDLC). A significant difference in LDL and calculated LDL was seen in case of borderline high category of cholesterol (200-239) where p (value)=0.000 which is less than level of significance 5%.