Aim: To evaluate and compare the Periodontal Inflamed Surface Area (PISA) in diabetics with periodontitis and non-diabetics with periodontitis. Materials and Methods: A total of 42 patients with Chronic Generalized Periodontitis, with and without type 2 diabetes mellitus, reporting to the Department of Periodontology, Sri Siddhartha Dental College and Hospital, Tumkur were selected for the study, taking into consideration the inclusion and exclusion criteria. Complete clinical examination of patients was carried out including probing pocket depth (PPD), Clinical attachment level (CAL), Gingival recession and Bleeding on probing (BOP). Data on all the 4 periodontal parameters, mentioned above, was assessed at six sites per tooth and entered in a spreadsheet to calculate PISA for each patient. HbA1c levels were estimated for all the patients by Glycosylated Hemoglobin kit. SPSS (Statistical Package for Social Sciences) version 20. (IBM SPASS statistics [IBM corp. released 2011]) was used to perform the statistical analysis.