Objective: This study aimed to compare the efficacy of lignocaine, ropivacaine, and bupivacaine in pain control during the extraction of mandibular posterior teeth. Methods: A total of 90 patients requiring extraction of mandibular posterior teeth were randomly assigned to three groups: lignocaine group (n=30), ropivacaine group (n=30), and bupivacaine group (n=30). All patients received local anesthesia via inferior alveolar nerve block. Pain intensity was assessed using a visual analog scale (VAS) immediately after the extraction and at 2, 4, 6, and 24 hours post-extraction. The total amount of rescue analgesics required was also recorded. Data were analyzed using one-way analysis of variance (ANOVA) and post hoc comparisons.