To study the antioxidant anti inflammatory property of selected fruit extracts of Hylocereus undatus, Litchi chinensis and Syzygium jambos using different model systems. The antioxidant potential was estimated by using hydroxyl radical, DPPH radical scavenging activities, hydrogen peroxide assay HRBC assay and albumin denaturation assay. The Litchi chinensis reported to have superior activity on hydroxyl radical, DPPH radical, and albumin denaturation assay and Hylocereus undatus reported to have hydrogen peroxide and HRBC stabilization assay. The antioxidant and anti-inflammatory activities might be due to the polyphenols present in the selected fruits