Ultrasonography(Usg) is the POINT OF CARE need in today’s practice of medicine. What makes it trendy is its under vision opportunity, precision, vigilance and the most important being SAFETY. With ultrasound guided blocks adding an adjuvant like beta agonists to local anaesthetics will further reduce the anxiety and offer sedation to high risk patients for whom brachial plexus block (BPB) will be an better option compared to general anaesthesia and its complications. Aim: To study such adjuvants which is been extensively used in today’s anaesthesia practice, i.e clonidine and dexmedetomedine with respect to BPB to observe the efficacy and potentiation in terms of a)Duration of motor and sensory blockade, b)Reduction of demand analgesia for NSAID’S, c)Total postoperative opioid need, d)Sedation score, e)Adverse events such as bradycardia, hypotension, loss of airway reflexes which needs treatment. Methodology: Patients recruited into 2 groups with one study drug allotted to each group. Surgery contemplated as per standard protocol using brachial plexus block with local anaesthetic mixture using Ropivacaine(2mg/kg) and lignocaine with adrenaline(4ml/kg) along with either dexmedetomedine or clonidine(1mcg/kg) under ulrasound guidance. Performance time and sedation score assessed intraoperatively along with hemodynamics. Postoperatively total analgesia and motor blockade duration, patient satisfaction score assesed and compared. Results: Demographics, hemodynamics, ultrasound performace time, intraoperative monitoring were all comparable amongst both groups. Total analgesia is typically prolonged with respect to Dexmedetomedine group(13.75 hours vrs 11.34 hours) and motor blockade which was dense was observed in clonidine group (12.85 hours versus 11.48 hours), both of which are statistically significant with p value <0.001 and 0.009 respectively. Conclusion: Using ultrasound and adjuvants will definitely enhance the efficiency of regional anaesthesia in today’s evidence based patient centered practice.